local divergence exponent

Gait variability in patients with COPD during a self-paced 6-minute walk test

Patients with chronic obstructive pulmonary disease (COPD) have an increased fall risk [1] and demonstrate gait deficits [2,3]. Gait variability has been associated with increased fall risk in the aging population [4]. However, studies reporting gait variability in COPD are scarce. Therefore, we aim to assess gait variability in patients with COPD during the 6-minute walk test (6MWT). Eighty patients with COPD (62±7yrs; FEV1:56±19%pred.) and 39 healthy subjects (62±6yrs; FEV1:119±17%pred.) performed two self-paced 6MWTs while kinematic parameters were recorded (100Hz, Vicon). The amount (coefficient of variation; CoV) and structure (sample entropy; SE) of variability of stride time, stride length and step width, and local divergence exponent (LDE) of the centre of mass velocity (CoMv) in three directions were computed. The sub-analysis accounted for gait speed influences on gait variability between groups. Stride time was longer (MD:0.13s, p<0.001) and stride length was smaller (MD:-0.30 m, p<0.001) in COPD. CoV for stride length was increased (MD:1.8%, p<0.001) and stride length SE was lower in COPD (MD:0.21, p<0.001). LDE for CoMv differed in vertical (MD: -0.12, p=0.001) and anteroposterior direction (MD: 0.10, p=0.017). The CoV for stride length remained higher in COPD (MD:1.0%, p=0.003) and stride length SE remained lower in COPD (MD:-0.12, p=0.011), after the sub-analysis of 14 patients with COPD and 14 healthy subjects with comparable walking speeds (MD:-0.02m/s, p=0.588). Patients with COPD demonstrate alterations in the amount and structure of variability in stride length, indicating alterations in the control of stride length variability patterns.
Listed In: Biomechanics, Gait