Instrumented Die

Optimization and design modeling for continuous roll compaction granulation

In granulation processes, the mechanical properties of the powder being processed are very influential on the characteristics of the end product. For this reason the modified Drucker-Prager/Cap model parameters of Micro-crystalline cellulose (MCC), a commonly used pharmaceutical excipient was determined. In particular, the influence of particle size of MCC on the DPC parameters was studied. In this study three grades of MCC (MCC 101, MCC102 & MCC200) were studied. It was found that the compaction properties were insensitive the particle size of MCC.

Listed In: Mechanical Engineering